<$BlogRSDUrl$> Marcus P. Zillman, M.S., A.M.H.A. Author/Speaker/Consultant
Marcus P. Zillman, M.S., A.M.H.A. Author/Speaker/Consultant
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Wednesday, March 09, 2005  

Oncogenomics Normal Tissue Database
http://ntddb.abcc.ncifcrf.gov/cgi-bin/nltissue.pl

The Oncogenomics Section of the Pediatric Oncology Branch announces the release of a high-density gene expression database derived from 42,000 clone cDNA microarrays containing 18,927 unique genes for 158 normal human samples from 19 different organs of 30 different individuals. Following a simple registration procedure, the user has full access to the entire dataset. Users are able to query genes based on IMAGE Clone ID, LocusLink number, Gene Ontology Terms, Gene Ontology ID, Gene Symbol, UniGene ID, Clone Title, Cytoband, and Chromosome. Three normalization options exist for the user to choose from: log2, median-centered log2, and median z-scored log2. The results of the query can be viewed by either a heatmap for multiple genes grouped by organ type or a bar-chart for individual genes also grouped by organ type. Links to various external databases populate the details page when an individual clone is selected. In the details page clones/genes that correlate (hence potentially co-regulated and in the same pathway) with that individual clone can be extracted. Future database developments will focus on enhanced queries which will allow the user to search based on gene expression ratios for the various organ types. Additionally, other organs and diseased tissues will also be added. The data base will be of use to many investigators working on a broad range of human diseases as well as those involved in drug development. This has been added to Biological Informatics Subject Tracer™ Information Blog.

posted by Marcus Zillman | 4:00 AM
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